Regioselective Suzuki-Miyaura Reaction: Application to the Microwave-promoted Synthesis of 4,7-Diarylquinazolines
نویسندگان
چکیده
منابع مشابه
Regioselective Suzuki-Miyaura reaction: application to the microwave-promoted synthesis of 4,7-diarylquinazolines.
New diarylquinazolines displaying pharmaceutical potential were synthesized in high yields from 4,7-dichloro-2-(2-methylprop-1-enyl)-6-nitroquinazoline by using microwave-promoted regioselective Suzuki-Miyaura cross-coupling reactions.
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The application of the Suzuki-Miyaura reaction in the synthesis of flavonoids, an important class of natural products, is reviewed. This reaction has not only been employed to provide access to flavonoid nuclei, but has also been applied to the synthesis of dimeric flavonoids and in the synthesis of libraries of flavonoid derivatives for biological activity studies. The classes of flavonoids th...
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Vindoline and its analogues are important constituents of the Madagascan periwinkle Catharanthus roseus, and some of them are valuable chemotherapy drugs used in treatment for some types of cancer, including leukaemia, lymphoma, breast and lung cancer. The search for semi-synthetic congeners of natural substances is still an important task for organic chemistry. In this communication we report ...
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The coupling reaction of phenylboronic acid with 4-silyl-bromobenzenes incorporating an ionic liquid support or its neutral analogue at 80 °C in DMF/H2O in the presence of Pd(PPh3)4 and Na2CO3 takes place much faster and more efficiently under microwave irradiation than under traditional heating. It is an attractive method to carry out the generally slow Suzuki–Miyaura reactions under microwave...
متن کاملRecent developments in the Suzuki-Miyaura reaction: 2010-2014.
The Suzuki-Miyaura reaction (SMR), involving the coupling of an organoboron reagent and an organic halide or pseudo-halide in the presence of a palladium or nickel catalyst and a base, has arguably become one of most utilized tools for the construction of a C-C bond. This review intends to be general account of all types of catalytic systems, new coupling partners and applications, including th...
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ژورنال
عنوان ژورنال: Molecules
سال: 2010
ISSN: 1420-3049
DOI: 10.3390/molecules15052949